Abstract

HIV associated TB is a major public health problem. In 2006, it was estimated that there were over 700,000 people who suffered from HIV associated TB, of whom about 200, 000 have died. The burden of HIV associated TB is greatest in Sub-Saharan Africa where the TB epidemic is primarily driven by HIV. There has been steady progress made in reducing the burden of HIV in TB patients with an increasing number of TB patients tested for HIV and provided with cotrimoxazole preventive therapy (CPT) and anti-retroviral treatment (ART). Less progress is being made to reduce the burden of TB in people living with HIV. The number of HIV infected persons reported to have been screened for TB was less than 1% while Isoniazid preventive therapy was reported to have been provided to less than 0.1% of eligible persons in 2006. A major push is urgently needed to accelerate the implementation of three important interventions. The three are Intensified TB Screening (ICF) among people living with HIV, the provision of Isoniazid Preventive Therapy (IPT) and TB Infection Control(IC). These interventions are best carried out by HIV control programmes which should therefore be encouraged to take greater responsibility in implementing these interventions.

Highlights

  • It is estimated that two thirds of the world population, or nearly two billion people, is infected with the tuberculosis bacillus[1] while about 33 million people were living with HIV by the end of 2007[2]

  • The TB and HIV epidemics are so intricately intertwined in SubSaharan Africa that the prevention and care of one must be linked with the prevention and care of the other [4]

  • Tuberculosis threatens the gains being made in the provision of anti-retroviral treatment (ART) to people living with HIV

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Summary

Introduction

It is estimated that two thirds of the world population, or nearly two billion people, is infected with the tuberculosis bacillus[1] while about 33 million people were living with HIV by the end of 2007[2]. As the HIV epidemic unfolded and TB was recognized to be a major problem in HIV infected persons, a series of studies designed to test the efficacy of Isoniazid in preventing HIV associated TB were carried out.

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