Abstract
The conformations of four series of alanine oligomers containing solubility-enhancing blocking groups were investigated using circular dichroism (CD) in trifluoroethanol (TFE), hexafluoroisopropanol (HFIP), and TFE-sulfuric acid, TFE-water mixtures. These studies show that alanine oligomers may exist in α-helical, β-associated, or disordered conformations, depending upon the solvent. The β-conformation, which appears in the higher oligomers, could be disrupted by dilution or by the addition of small amounts of sulfuric acid (1%). A mixture of 99% TFE-1% H 2SO 4 was found to be helix supporting and was used to determine a critical size for helix formation. Studies in TFE-water suggest that the higher oligomers should exist in a β-conformation in water.
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