Abstract

The nucleosides Ia and IIa exist in syn and anti conformations, respectively, both in solid state and solution. Compound Ia undergoes significant conformational change, accompanied by increased population of the anti conformer, upon conversion to the corresponding 5′-mono- and-diphosphate derivatives, whereas conformation of IIa remains reasonably constant between nucleoside and nucleotides. While Ia possessed the C2′- endo C3′- exo geometry, IIa had the opposite C2′- exo - C3′- endo conformation. The C5′ of the two nucleosides bore axial and equatorial conformations, respectively.

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