Conformational properties of 3′-azido-3′deoxy-thymidine (AZT), an inhibitor of HIV reverse transcriptase

Abstract

The low-energy conformations of 3′-azido-3′-deoxy-thymidine, (AZT), an inhibitor of retroviral reverse transcriptase, have been studied by molecular mechanics techniques. A force-field has been developed for the azido group by quantum-mechanical methods, and used in the analysis. The global low-energy structure of AZT has C3′- endo sugar pucker, an anti glycosidic angle, and a g + C4′–C5′ conformation. It is concluded that the AZT molecule has conformational properties that are very similar to those of standard deoxypyrimidines.