Abstract
In order to explain the separate α-CH peaks in NMR spectra of polypeptides in the helix—coil transition region, the lifetimes of molecules in two sites (one being a totally random-coil conformer and the other, comprising all other conformers containing at least one helix unit), were calculated on the basis of the one-dimensional Ising model in accordance with a two-site model. A lifetime greater than 10−2 s was not obtainable for a totally random-coil conformer for chain lengths ranging from 10 to 85. It was concluded that the occurrence of the separate peaks could not be attributed to the slow exchange rate between the two sites. Polydispersity in the chain length seems to be major consequence of such separate peaks.
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