Abstract

The X-ray crystal structure of [Pt(en)(CBDCA-O,O′)] 1, an analogue of the anticancer drug carboplatin, shows that platinum has an approximate square-planar coordination. The crystals are orthorhombic with space group Pnma. The Pt-CBDCA chelate ring adopts a flattened-boat conformation, similar to that found for carboplatin, and the Pt-ethylenediamine chelate ring exhibits both δ and λ conformations with equal populations. Ethylenediamine chelate ring inversion was observed by 13C CP/MAS NMR spectroscopy. The exchange rate and the activation free energy (ΔG‡) at 317 K were determined to be ca. 415 s-1 and 62 kJ mol-1, respectively. The CBDCA ligand appears to have a direct effect on the dynamics of the en ring. Conformational flexibility of the CBDCA ring is also discussed. Such dynamic processes within chelated platinum complexes could play a role in the biological recognition of anticancer complexes.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.