Abstract
Background: White birch and hazel allergens, namely Bet v1 and Cor a1 are known allergens, but their allergen specificity is not yet characterized.
 Objective: To map the antigenic determinants responsible for IgE binding utilizing in silico modelling and docking of the peptides against IgE antibody.
 Methods: The antigen sequences were cut into peptides are docked against the IgE antibody and those with the highest docking scores are further studied for the bond interactions. The overlapping sequences of the high score peptides are observed in the whole antigen model to predict their position. The residues at bond interactions also been reported for these overlapping peptide sequences.
 Results: The validation is done by antigen-antibody docking studies to confirm the predicted epitope. 25% of the world population suffers from allergic rhinitis and 15% of them develop asthma. Conclusion: Negative binding energies of the studied pollen allergens with IgE confirm their allergenicity. Based on the results of overlapping peptides PF 3,4 and PF 16,17 to play a key role in the allergenic response of white birch and Common hazel.
Highlights
In the adaptive immune system, B cells play an essential role in protecting the human body against various pathogenic molecules
The birch pollen (Bet v1) and hazel pollen (Cor a1) sequences are cut into a length of 10-mers with a gap of five amino acids
The bond interactions is seen between overlapping peptide fragments of Bet v1, Cor a1 and immunoglobulin E (IgE) antibody (Tables 3 and 4)
Summary
In the adaptive immune system, B cells play an essential role in protecting the human body against various pathogenic molecules. The major plant allergens of white birch (Betula verrucosa) and common hazel (Corylus avellana) are the antigens chosen for this analysis. Allergic hypersensitivity or allergy is a reaction that happens in an individual when the same allergen is introduced into that person who has developed IgE antibodies in response to that antigen or allergen priorly [2]. The present work focused on the in silico molecular characterization of white birch and common hazel Bet v1 and Cor a1 allergen-derived peptides, respectively. Methods: The antigen sequences were cut into peptides are docked against the IgE antibody and those with the highest docking scores are further studied for the bond interactions. Based on the results of overlapping peptides PF 3,4 and PF 16,17 to play a key role in the allergenic response of white birch and Common hazel
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