Abstract
Neurotransmitter release via synaptic vesicle exocytosis is mediated by the dynamic assembly and disassembly of the neuronal SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex, which consists of syntaxin-1, SNAP-25, and synaptobrevin-2. Despite their importance, the molecular mechanism of SNARE complex recycling remains unclear. Individual SNARE proteins are intrinsically disordered and undergo a disorder-to-order transition, which assembles into a highly stable four-helix bundle, providing the energy required to drive membrane fusion between the synaptic vesicle and the plasma membrane.
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