Conformational dynamics and functional characterization of the C-terminal tail of Myosin 16

Abstract

The lesser-known unconventional myosin 16 protein is crucial in neuronal functioning and has been implicated in cell cycle regulation. Its longer Myo16b isoform contains a C-terminal tail extension (Myo16Tail), which has been shown to play a role in the neuronal phosphoinositide 3-kinase signaling pathway. Myo16Tail mediates the actin cytoskeleton remodeling, as well as downregulates the actin dynamics at the postsynaptic site of dendritic spines and involved in the organization of the presynaptic axon terminals.