Abstract
Experimental and theoretical conformational analysis of N-methyl-N-[2-(diphenylphosphoryl)ethyl]diphenylphosphorylacetamide, N-butyl-N-[2-(diphenylphosphoryl)ethyl]diphenylphosphorylacetamide, and N-octyl-N-[2-(diphenylphosphoryl)ethyl]diphenylphosphorylacetamide was carried out by the methods of dipole moments, IR spectroscopy, and Density Functional Theory (DFT) B3PW91/6-311++G(df,p) calculations. In solution, these N,N-dialkyl substituted bisphosphorylated acetamides exist as a conformational equilibrium of several forms divided into two groups—with Z- or E-configuration of the carbonyl group and alkyl substituent, and syn or anti arrangement of the phosphoryl-containing fragments relative to the amide plane. The substituents at the phosphorus atoms have eclipsed cis- or staggered gauche-orientation relative to the P=O groups, and cis orientation of the substituents is due to the presence of intramolecular H-contacts P=O...H−Cphenyl or p,π conjugation between the phosphoryl group and the phenyl ring. Preferred conformers of acetamides molecules are additionally stabilized by various intramolecular hydrogen contacts with the participation of oxygen atoms of the P=O or C=O groups and hydrogen atoms of the methylene and ethylene bridges, alkyl substituents, and phenyl rings. However, steric factors, such as a flat amide fragment, the bulky phenyl groups, and the configuration of alkyl bridges, make a significant contribution to the realization of preferred conformers.
Highlights
Derivatives of carbamoylmethylphosphine oxides (CMPO) are known as effective extractants of rare earth elements and actinides from mineral acid solutions [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17]
The crys-and the tal structures ofmethyldiphenylphosphine oxide and protonated conformational analysis by the methods of dipole momentsitsand quantum ch form [32], diphenylmorpholine carbamoylmethyl phosphine oxide [33], diphenyl-N,Nshowed that in solution, these compounds exist as an equilibrium of several con dimethylcarbamoylmethylphosphine oxide [34], N-aryl-substituted CMPO modified with intramolecular
2, In the present work, we investigated the spatial structure of N-methyl-N-[2-(diphenylN-octyl-N-[2-(diphenylphosphoryl)ethyl]diphenylphosphorylacetamide
Summary
Derivatives of carbamoylmethylphosphine oxides (CMPO) are known as effective extractants of rare earth elements and actinides from mineral acid solutions [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17]. Carbamoylmethylphosphine oxides have found active practical applicamodified with a phosphoryl group, and its complexes with Pd (II) and Re (I) [3 tion for a long time, their spatial structure has been poorly studied. The crys-and the tal structures of (diethylcarbamoyl)methyldiphenylphosphine oxide and protonated conformational analysis by the methods of dipole momentsitsand quantum ch form [32], diphenylmorpholine carbamoylmethyl phosphine oxide [33], diphenyl-N,Nshowed that in solution, these compounds exist as an equilibrium of several con dimethylcarbamoylmethylphosphine oxide [34], N-aryl-substituted CMPO modified with intramolecular [36]. CMPOs: experimental and theoretical conformational compounds and explaining the reaction mechanisms with analysis their partic by the methods of dipole moments and quantum chemistry showed that in solution, these.
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