Abstract
Stimuli-responsive nanoparticles are among the most popular research topics. In this study, two types of core-shell (polystyrene with a photoiniferter (PSV) as the core and diblock as the shell) polymer brushes (PSV@PNIPA-b-PAA and PSV@PAA-b-PNIPA) were designed and prepared using surface-initiated photoiniferter-mediated polymerization (SI-PIMP). Moreover, their pH- and temperature-stimuli responses were explored by dynamic light scattering (DLS) and turbidimeter under various conditions. The results showed that the conformational change was determined on the basis of the competition among electrostatic repulsion, hydrophobic interaction, hydrogen bonding, and steric hindrance, which was also confirmed by protein adsorption experiments. These results are not only helpful for the design and synthesis of stimuli-responsive polymer brushes but also shed light on controlled protein immobilization under mild conditions.
Highlights
IntroductionCore-shell nanoparticles have received increasing interest. As core-shell structure nanoparticles, spherical polymer brushes are formed by attaching one end of the polymer chain to a core surface
In recent years, core-shell nanoparticles have received increasing interest
We found that the conformational change of the polymer brushes was a result of the competition between electrostatic repulsion, hydrophobic interaction, hydrogen bonding, and steric hindrance
Summary
Core-shell nanoparticles have received increasing interest. As core-shell structure nanoparticles, spherical polymer brushes are formed by attaching one end of the polymer chain to a core surface. Cang et al explored the temperature-sensitive performance of the copolymerization brush polystyrene@poly(N-isopropyl acrylamide)-co-poly(acrylic acid) (PS@PNIPA-co-PAA) with different acrylic acid (AA) additions under different pH values [31]. These polymer brush chains are randomly copolymerized with structural uncertainties and uncontrollability present the problem of a “loss” of thermo-sensitivity, even when a small amount of AA is added [31,32]. Shi et al grafted block poly(N-isopropyl acrylamide)-b- poly(2-succinyloxyethyl methacrylate) (PNIPA-b-PSEM) on the gold surface through ATRP; the nanoparticles showed good temperature sensitivity and pH responsiveness and showed photo-induced thermosensitivity because of the presence of the gold nucleus [18].
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