Abstract

THE biological activity of quaternary aryloxyethylammonium salts is critically dependent on the nature and position of the substituents in the aromatic ring1–3. Thus choline phenyl ether bromide is a potent nicotine-like ganglion stimulant2,4, whereas its 2,6-dimethyl analogue (xylocholine) is devoid of ganglion stimulant activity5 but was the first compound to exhibit adrenergic neurone blocking activity6–9. Xylocholine also has muscarine-like properties6–9.

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