Conformation of 2- C,1- N-carbonyl-2-deoxy-α- d-glycopyranosylamines

Abstract

The conformations of 2- C:1- N-carbonyl-2-deoxyglycopyranosylamines (β-lactams) with the α- d- gluco, α- d- galacto, β- d- arabino, α- l- xylo, α- l- gluco, and β- d- altro configurations have been investigated by X-ray crystallography and n.m.r. spectroscopy. The n.m.r. data, interpreted in terms of an equilibrium of two rapidly interconverting half-chair forms, were supported strongly by the diffractometric data which showed almost regular half-chair conformations.