Abstract
By mimicking the variable resolution of the human eye, a newly designed foveated endomicroscopic objective shows the potential to improve current endoscopic based techniques of identifying abnormal tissue in the esophagus and colon. The prototype miniature foveated objective is imaged with a confocal microscope to provide large field of view images combined with a high resolution central region to rapidly observe morphological structures associated with cancer development in a mouse model.
Highlights
Accounting for approximately 28 percent of the deaths due to cancer in the United States, gastrointestinal carcinomas result in more deaths around than the world than all other malignancies [1]
We have addressed these concerns through the development of a multimodal foveated endomicroscope system
The work presented here is focused on the design, fabrication and validation of the foveated endomicroscope objective integrated with a confocal microscope
Summary
Accounting for approximately 28 percent of the deaths due to cancer in the United States, gastrointestinal carcinomas result in more deaths around than the world than all other malignancies [1]. A recent study suggested that a combination of HDWLE with NBI or some other visual enhancement technique with a higher optical resolution imaging modality such as confocal imaging could improve sensitivity of detection by resolving the adequate spatial details to identify neoplastic progression [9]. In order to improve upon the deficiencies of current optical biopsy techniques, a single miniature system needs to combine high resolution imaging with the broad screening capabilities of enhanced visualization techniques. We have addressed these concerns through the development of a multimodal foveated endomicroscope system. The work presented here is focused on the design, fabrication and validation of the foveated endomicroscope objective integrated with a confocal microscope
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