Abstract
A 52-year-old woman with a 20-year history of ulcerative colitis (UC) underwent surveillance colonoscopy. She had received prednisone and then started infliximab therapy 4 months before colonoscopy for diarrhea and rectal bleeding, which resolved, but arthralgias and paresthesias led to infliximab discontinuation after the third induction dose. At the time of colonoscopy, the patient was asymptomatic on mesalamine monotherapy. Colonoscopy revealed only left-sided colitis and pseudopolyps abutting the anal verge. Random biopsies revealed moderate active colitis consistent with UC in the distal 40 cm of the colon. Rectal biopsy specimens 10 cm from the anus incidentally also contained areas of squamous epithelium with at least intermediate-grade squamous intraepithelial neoplasia. Biopsies of the distal rectum revealed inflammatory pseudopolyps as well as squamous epithelium with high-grade squamous intraepithelial neoplasia.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
