Abstract
Oxidative stress has been shown to mediate damage to metaphase II (MII) mouse oocyte microtubule (MT) and chromosome (CH) structure; markers of oocyte quality. Our long term goal is to utilize confocal 3-Dimensional (3-D) imaging as a tool to: 1) quantitate spindle damage; 2) elucidate the mechanism by which reactive oxygen species (ROS) mediate spindle damage in inflammatory states and aging. The objective of this study was to utilize confocal 3-D visualization to assess peroxynitrite (ONOO-) mediated damage to oocyte spindle.
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