Conflicting and non-conflicting visual cues lead to error in gait initiation and gait inhibition in individuals with freezing of gait

Abstract

IntroductionWe asked whether conflicting visual cues influences gait initiation, gait inhibition and postural control in Parkinson’s disease (PD) between freezers, non-freezers and healthy older adults. MethodsTwenty-five PD participants on dopaminergic medication and 17 healthy older adults were asked to initiate or refrain gait depending on visual cues: green GO (GG), green STOP (GS), red GO (RG), red STOP (RS). Center of pressure (CoP) displacement, variability and mean velocity (VCoP) in the anterior-posterior (AP) and medial-lateral (ML) directions and movement time (MT) were measured. ResultsGait initiation: Both freezers and non-freezers were different from controls in GG and GS. In GS, freezers had smaller CoP displacement and velocity in both directions (p<0.01), while non-freezers had smaller VCoP in AP and ML (p<0.01). AP CoP displacement in GS was smaller in freezers compared to non-freezers (p<0.05). Freezers had longer MT compared to controls in GG and compared to both groups in GS (p<0.01). Gait inhibition: Controls and freezers had larger CoP displacement variability (p<0.05) and velocity (p<0.01) in both directions in RG compared to RS. No differences were seen in non-freezers. Three freezers initiated walking during the RG or RS conditions. ConclusionFreezers were in general slower at initiating gait, displayed a more restrictive postural strategy and were more affected by the conflicting conditions compared to both controls and non-freezers. In freezers, the conflicting visual cues may have increased the cognitive load enough to provoke delays in processing the visual information and implementing the appropriate motor program.