Abstract
The configuration of nearly monodisperse tobacco mosaic virus (TMV) ribonucleic acid (RNA) of molecular weight 2·0 ± 0·1 million was studied at 20 to 25°C in 0·1 M-sodium phosphate buffer, pH 6·8, by light scattering, sedimentation, viscosity, optical rotary dispersion, and optical absorbance measurements. Results show that the partly helical configuration stable under these conditions behaves hydrodynamically as a randomly coiled polymer chain. The RNA chain becomes more compact when solutions are heated briefly to temperatures as high as 80°C and cooled rapidly, or allowed to stand at 25°C for 2 days, no change in molecular weight or distribution being observed under these conditions.
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