Cone photoreceptors in human stem cell-derived retinal organoids demonstrate intrinsic light responses that mimic those of primate fovea.

Abstract

(Cell Stem Cell 29, 460–471.e1–e3; March 3, 2022) In the originally published, online version of the manuscript, the authors mistakenly included the incorrect traces for Figure 2B denoted as foveal cone responses. To address this oversight, the authors have replaced Figure 2B and included the correct traces for foveal cone responses along with the accurate y axis units. In addition, there were a few typographical errors as detailed below that have been corrected.(1)Figure 1E legend: the number of foveal cones in the bar graph is not n = 6. Instead, the number of foveal cones is 14; i.e., n = 14. This was also mentioned in the originally published version of Table S2.(2)Figure 1H legend: the legend for Figure 1I was mistakenly referred to as being the legend for Figure 1H, which has now been corrected. The missing legend for Figure 1H is now included as follows: “(H) Exemplar voltage responses of a dark-adapted macaque foveal cone to 10 ms flashes of light intensities of 25, 75, and 150 R∗/cone/flash.”(3)Figure 4B legend: “RO cones at d230–d260 had the maximum sensitivity to the light flash” has now been edited to read, “RO cones at d250–d260 had the maximum sensitivity to the light flash,” as mentioned in the Results section.(4)Supplemental figure legends: In Figures S1E and S1F, the legend refers to “white/yellow” arrowheads in the image panels, which instead should read “black” arrowheads. The scale bar in Figure S1F should be 0.8 μm and not 0.5 μm. In Figure S2, the authors have in addition mentioned the exact time point of light stimulus (time = 100 ms), which was not included in the originally published version of the manuscript. All the changes above have been incorporated in the revised online version as well as in the print version of the paper. The authors apologize for the oversight and for any resulting confusion.Figure 2RO cones respond over a wide range of mean luminance, originalView Large Image Figure ViewerDownload Hi-res image Download (PPT) Cone photoreceptors in human stem cell-derived retinal organoids demonstrate intrinsic light responses that mimic those of primate foveaSaha et al.Cell Stem CellJanuary 30, 2022In BriefSinha and colleagues show that human stem cell-derived ROs contain cone photoreceptors that possess intrinsic light sensitivity with complex electrophysiological attributes that approach those of adult primate foveal cones. Full-Text PDF