Abstract
Conductance values of nimesulide have been determined in water in 0.1, 0.2, 0.4, 0.6, 0.8, 1 and 2 mol dm-3 aqueous solutions of hydrotropic agents (sodium benzoate, sodium salicylate, sodium bromide and nicotinamide) at temperatures 298.15, 303.15, 308.15 and 313.15 K. The conductance values have been used to evaluate the limiting molar conductance and association constants by means of Shedlovsky extrapolation technique. Thermodynamic parameters for the association process of nimesulide in aqueous solutions of hydrotropic agents have also been calculated.
Highlights
Solubility and permeability are the two key biopharmaceutical parameters responsible for effective bioavailability and good in vitro and in vivo correlation[1]
As the limiting molar conductivity values, Λ0 obtained by two methods using the values of ion-size parameter, a0= 0, q and 2q are very close to each other, as presented else where[7], the values of the Λ0 for a0= q are given in Table 1 for the Shedlovsky method only and so the values of KA, the association constants of hydrotropic agents and of nimesulide in aqueous solutions of hydrotropic agents at experimental temperatures
It is noted that the obtained Λ0 values of the hydrotropic agents in water are in good agreement with the values that are available in the literature[12]
Summary
Solubility and permeability are the two key biopharmaceutical parameters responsible for effective bioavailability and good in vitro and in vivo correlation[1]. We have reported volumetric and viscometric studies on nimesulide in aqueous solutions of four different hydrotropic agents (sodium benzoate, sodium salicylate, sodium bromide and nicotinamide) at different temperatures, so as to highlight the solute-solvent interactions correlating the solubility findings[6].
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