Abstract

Conductometric method development and validation to estimate acamprosate calcium in API and marketed formulation

Highlights

  • Acamprosate calcium is a calcium salt of acetylhomotaurine which is used for the treatment of alcohol dependence, which acts by stabilizing the chemical balance in the central nervous system, by blocking glutaminergic N-methyl-D-aspartate receptors and activation of gamma-aminobutyric acid (GABA) type A receptors (Rhee et al, 2008a; Saivin et al, 1998; Zornoza et al, 2003)

  • The Liquid Chromatography mass spectrometry (LCMS) method for bioanalytical analysis, LC-fluorometric, and electrochemical detection was reported in human plasma, dog plasma, and urine (Chabenat et al, 1987, 1989; Ghosh et al, 2011; Girault et al, 1990; Hammarberg et al, 2010; Kanala et al, 2013; Rhee et al, 2008a; Rhee et al, 2008b; Xu et al, 2009)

  • Fifty milligram of the active pharmaceutical ingredient was dissolved in 50 ml of a volumetric flask and the final volume was made with distilled water; from the above solution, 0.5–2.5 ml was pipetted and transferred in 10 ml of a volumetric flask and the final volume was made with distilled water to obtain 50–250 μg/ml of pure acamprosate calcium

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Summary

INTRODUCTION

Acamprosate calcium (calcium 3-acetamidopropane-1sulfonate; Figure 1) is a calcium salt of acetylhomotaurine which is used for the treatment of alcohol dependence, which acts by stabilizing the chemical balance in the central nervous system, by blocking glutaminergic N-methyl-D-aspartate receptors and activation of gamma-aminobutyric acid (GABA) type A receptors (Rhee et al, 2008a; Saivin et al, 1998; Zornoza et al, 2003). This drug is available since 1989 in the tablet strength of 333 mg (Lipha Pharmaceuticals Inc., 2002). A new cost-effective, precise, and regression co-efficient on electrical conductivity method on acamprosate calcium in pure and marketed formulation is reported

MATERIALS AND METHODS
Method development
Method validation
RESULT
DISCUSSION
Findings
CONCLUSION
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