Conducto metric Studies on the Thermal Effects on Micellar Solubilization of Acetazolamide - A Diuretic Drug

Abstract

Drugs solubility is an important parameter for efficient absorption and drug delivery. Thus, most exigent phase of drug development practice particularly for oral dosage forms is the enhancement of drug solubility. Acetazolamide is a drug with diuretic properties. Conductivity measurement have been carried out to study the micellar behavior of anionic surfactant i.e., sodium dedocyl sulphate (SDS) and cationic surfactant i.e. cetyl trimethyl ammonium bromide (CTAB) in the absence and presence of a diuretic drug i.e. Diamox in the temperature range of 25°C – 45°C. From the measurements, various physicochemical and surface properties Critical micellar concentration (cmc), thermodynamic parameters (ΔG°m, ΔH°m , ΔS°m) have been determined. The negative value of ΔG°m shows spontaneity of solubilization process. All these parameters have been discussed in terms of drug-drug, drug-solvent and drug-surfactant interactions. This result shows that the solubility of Acetazolamide drug increases with increasing the concentration of both anionic and cationic surfactant. This study reveals that use of surfactant in pharmacy is an important tool for finding numerous applications.