Abstract
An electrochemical sensor for paracetamol is executed by using conductive MOF (NiCu-CAT), which is synthesized by 2, 3, 6, 7, 10, 11-hexahydroxytriphenylene (HHTP) ligand. The utility of this 2D NiCu-CAT is measured by the detection of paracetamol, p-stacking within the MOF layers is essential to achieve high electrical conductivity, redox activity, and catalytic activity. In particular, NiCu-CAT demonstrated detection Limit of determination near 5μM for paracetamol through a wide concentration range (5–190 μM). The NiCu-CAT/GCE exhibits excellent reproducibility, stability, and interference for paracetamol.
Highlights
Paracetamol (PA) is a high effective antipyretic and analgesic drug, which is generally used to relieve moderate pain, such as headache caused by influenza or joint pain, migraine, etc
Powder X-ray diffraction (PXRD) data were collected on a Rigaku D/max-2,550 diffractometer with CuKα radiation (λ = 1.5418 Å)
The peak currents of five tests were recorded to study the reproducibility of the NiCu-CAT/glassy carbon electrode (GCE) by differential pulse voltammetry (DPV), and the same electrode was modified five times for PA detection at the same concentration of 40 μM (Figure 6a)
Summary
Paracetamol (PA) is a high effective antipyretic and analgesic drug, which is generally used to relieve moderate pain, such as headache caused by influenza or joint pain, migraine, etc It regulates the synthesis and release of central prostaglandins by controlling the body temperature in the hypothalamus, improves the pain threshold and plays the role of antipyretic and analgesic (Wan et al, 2009; Ghadimi et al, 2013). The existing detection methods include spectrophotometry, titration analysis, chemiluminescence, capillary electrophoresis, fluorescence spectrum, highperformance liquid chromatography (Easwaramoorthy et al, 2001; Bosch et al, 2006). It is not suitable for the rapid detection of PA in daily life due to the complex pretreatment, large equipment, time-consuming and expensive of these existing detection methods. Researchers have developed high catalytic activity nanomaterials for the design of highly sensitive paracetamol electrochemical sensors (Ejaz and Jeon, 2017; Raymundo-Pereira et al, 2017; Zhao et al, 2019)
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