Abstract
A conditioned place preference paradigm was used to examine the motivational effects of the putative 5-hydroxytryptamine 1A (5-HT 1 A ) receptor agonist 8-hydroxy-2-(di- n-propyl amino)tetralin (DPAT). Rats exhibited marked preferences for an environment paired with the s.c. injection of DPAT (0.1–0.25 mg/kg): vehicle injections were without effect. Pretreatment with the 5-HT 1A/D 2 dopamine (DA) receptor antagonist spiperone or the D 1 DA receptor antagonist SCH-23390 abolished the DPAT-induced preferences. The D 2 antagonist sulpiride was without effect. These data demonstrate that DPAT is an appetitive reinforcer and that this effect results from an interaction with 5-HT 1 A and D 1 DA receptors. They further suggest that 5HT 1 A agonists may have potential for abuse.
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