Conditional Control of Fluid Consumption in an Occasion Setting Paradigm Is Independent of Pavlovian Associations

Abstract

Drug states, flavors, and contextual cues were each trained as conditional discriminative stimuli to control a saccharin-LiCl association. In transfer tests, drug states transferred control over consumption to other flavored solutions and to food. Contexts and flavors transferred control only to other flavored solutions. Pavlovian control groups given direct pairings of context-LiCl or flavor-LiCl did not show reliable transfer. However, these control groups did show greater or the same aversion to the specific context or flavor predicting LiCl compared to the context or flavor discrimination groups. The dissociation of the discrimination and Pavlovian groups on transfer versus preference tests suggests that performance on the occasion setting task cannot be due to simple excitation or learning about a unique compound cue. Data from extinction procedures provide further support for the dissociation between simple excitation and occasion setting.