Abstract
Condensation of benzil, 1 with resorcinol in the presence of potassium carbonate at 110-120°C gave the mixture of the compounds. Using various kinds of separation technique only five types of the polymeric products, a1, a2, a3, a4 and a5 were isolated. The compounds a1, a4 showed high cytotoxic activity and the compounds a2, a3 and a5 showed relatively low cytotoxic activity against the brine shrimp lethality bioassay.
Highlights
Various types of substituted heterocyclic compounds were synthesized and cytotoxic activity of these compounds have been found by screening tests (Islam et al, 2001a; Islam et al, 2001b; Lingcon et al, 2001)
IR spectra were recorded on a Shimadzu DR 8001 FT-IR spectrometer, NMR spectra on a WP 200 spectrometer using TMS as internal standard and mass spectra on an MS Kratas mass spectrometer
The mixture of the products, PM was washed with water and this water soluble portion was extracted by chloroform and TLC examination of the product, a1 showed the single spot
Summary
Various types of substituted heterocyclic compounds were synthesized and cytotoxic activity of these compounds have been found by screening tests (Islam et al, 2001a; Islam et al, 2001b; Lingcon et al, 2001). After collecting the PLDM product, this portion was separated by column chromatography on silica gel using pet ether and ethyl acetate. The 6th fraction in Table I was taken for PTLC method for further separation and pet ether and ethyl acetate were used as solvent (EA:PE=3:2).
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