Abstract
BackgroundTo investigate the clinical manifestation, diagnosis, treatment, and outcome of simultaneous occurrence of renal cell carcinoma (RCC) and urothelial carcinoma.MethodsTwenty-seven consecutive patients with synchronous renal cell carcinoma and urothelial carcinoma treated in two tertiary medical centers from March 2005 to December 2015 were retrospectively reviewed. Their clinical, pathological, and prognostic features were evaluated. Kaplan-Meier curves were used to estimate overall survival.ResultsThe median age was 69 years (range, 37–79 years). Seventeen patients presented with macroscopic hematuria, and 10 patients were asymptomatic. B-ultrasound, computed tomography (CT), and cystoscopy initially indicated RCC concurrent with ipsilateral upper tract urothelial carcinoma (UTUC) in 5 cases, RCC concurrent with contralateral UTUC in 1 case, RCC concurrent with bladder tumor in 17 cases, RCC concurrent with both ipsilateral UTUC and bladder tumor in 1 case, RCC in 2 cases and ureter carcinoma in 1 case. Different treatments were performed. The median follow-up time after surgery was 23 months. For patients with synchronous RCC and bladder tumor, there was no significant survival difference between patients treated with partial nephrectomy and radical nephrectomy. During follow up, four patients died of RCC, three patients died of non-oncological disease, one patient died of ureter carcinoma. The 3-year overall survival rate was 80.8%.ConclusionsConcurrence of RCC and urothelial carcinoma is clinically rare. Treatments should be individualized. The prognosis for a patient with synchronous RCC and urothelial carcinoma is possibly associated with the more aggressive one.
Highlights
To investigate the clinical manifestation, diagnosis, treatment, and outcome of simultaneous occurrence of renal cell carcinoma (RCC) and urothelial carcinoma
To the best of our knowledge, this is the largest series of concurrent renal cell carcinoma and urothelial carcinoma ever reported in English literature
Clinical diagnosis of concurrent RCC and urothelial carcinoma was made in 24 patients (Figs. 1 and 2)
Summary
To investigate the clinical manifestation, diagnosis, treatment, and outcome of simultaneous occurrence of renal cell carcinoma (RCC) and urothelial carcinoma. Renal cell carcinoma (RCC) and urothelial carcinoma are both common urological malignancies. Their simultaneous occurrence in a patient is, extraordinarily rare. Most studies of synchronous RCC and urothelial carcinoma have been described in case report or small series. Due to the rarity of the disease and the limited reports in the literature, the treatment and outcomes of concurrent RCC and urothelial carcinoma are still uncertain, especially for patients with concurrent RCC and bladder tumor. To the best of our knowledge, this is the largest series of concurrent renal cell carcinoma and urothelial carcinoma ever reported in English literature
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