Concurrent Oral Sessions

Abstract

While HCV+ candidates are often viremic at transplant, most centers require HIV+ patients to be aviremic. Purpose: to compare the effect of HIV, HCV or HIV/HCV co-infection on kidney alone transplant outcomes. Methods: Retrospective UNOS registry study of patients transplanted 1/1/96-/12/31/12. Cox regression models were fit to examine patient and overall graft survival in HCV+ (n=5145), HIV+ (n=429) and HCV+/HIV+ (n=129) groups, with the HIV-/HCV- (n=106,288) group as reference. Covariates included those significant in unadjusted analysis and era effect, to account for changes in immunosuppression and HCV therapy. Results: Patient and graft survival in HIV+ patients did not differ significantly from the HIV-/HCV- group and was superior to both HCV+ and HCV+/HIV+ groups (table, figures). Conclusions: HIV does not affect kidney or recipient survival while HCV negatively impacts both. Pretransplant HCV eradication should be prioritized as a strategy to improve outcomes in this population.Table: No Caption available.Figure: No Caption available.Figure: No Caption available.