Concurrent Malignant Solitary Fibrous Tumor Arising from the Omentum and Grade 3 Endometrial Endometrioid Adenocarcinoma of the Uterus with p53 Immunoreactivity.

Naoya Harada,Sumire Ohno,Yumi Higashiura,Hideki Watanabe,Noriko Haruta,Ichiro Nobuhara

doi:10.1155/2014/216340

Naoya Harada, Sumire Ohno + Show 4 more

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https://doi.org/10.1155/2014/216340

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Journal: Case Reports in Obstetrics and Gynecology	Publication Date: Jan 1, 2014
Citations: 8	License type: CC BY 3.0

Affiliation: Nara City Hospital

Abstract

A malignant solitary fibrous tumor arising from the omentum is extremely rare. To our knowledge, this is the first case of a malignant solitary fibrous omentum tumor coexisting with uterine corpus cancer. A 62-year-old woman presented to our hospital with vaginal discharge. Endometrioid adenocarcinoma was diagnosed by endometrial curettage. In addition, a solid tumor in front of the uterus was detected following computed tomography and/or magnetic resonance imaging, which was suspected to be a primary (or secondary) malignant tumor arising from the omentum. Hysterectomy, bilateral salpingo-oophorectomy, omentectomy, and lymphadenectomy were performed. A malignant solitary fibrous tumor of the omentum and grade 3 endometrioid adenocarcinoma of the uterus were diagnosed by pathohistological analysis. Interestingly, the tumor cells were immunoreactive for p53. Adjuvant chemotherapy was administered for the uterine corpus cancer and the patient remains healthy 48 months after the surgery. These tumors may have become malignant due to the presence of p53 mutations.

Highlights

A solitary fibrous tumor (SFT) is a rare neoplasm mainly originating in the pleura; extrathoracic SFTs have been increasingly described, such as those in the meninges, liver, upper respiratory tract, orbit, thyroid, salivary gland, and female genital tract [1]
SFT is a rare neoplasm that is thought to originate from submesothelial mesenchymal cells [3]
This is the first case of a malignant SFT originating from the omentum complicated with uterine corpus cancer

Summary

Introduction

A solitary fibrous tumor (SFT) is a rare neoplasm mainly originating in the pleura; extrathoracic SFTs have been increasingly described, such as those in the meninges, liver, upper respiratory tract, orbit, thyroid, salivary gland, and female genital tract [1]. SFT of the peritoneum, one arising in the lesser omentum, is extremely rare [2]. SFTs are usually benign, malignant SFTs have been described in a limited number of reports [3,4,5,6,7,8]. A case of concurrent malignant SFT arising from the omentum and grade 3 endometrial endometrioid adenocarcinoma of the uterus has not been reported previously. The tumor cells were immunoreactive for p53.

Case Presentation

Discussion