Abstract
BackgroundRetroperitoneal high-grade serous carcinoma (HGSC) is extremely rare and the origin remains unclear. We present a case of retroperitoneal HGSC and coexisting serous tubal intraepithelial carcinoma (STIC), which is considered as the main origin of ovarian HGSC. We reviewed the available literature and discussed about the origin of this rare disease.Case presentationA 58-year-old female with a 93 × 65 × 62 mm-solid tumor with a cystic part was located immediately dorsal to the rectum underwent bilateral salpingo-oophorectomy, total abdominal hysterectomy, and en bloc resection of the retroperitoneal tumor together with lower anterior resection of the rectum. Histological diagnosis was retroperitoneal HGSC and STIC at the right fallopian tube. Two deleterious somatic mutations in TP53 and BRCA2 genes were shared between retroperitoneal HGSC and STIC.ConclusionsIn addition to clinical features in the previous reports, our genetic findings suggest the origin of retroperitoneal HGSC might be STIC.
Highlights
Retroperitoneal high-grade serous carcinoma (HGSC) is extremely rare and the origin remains unclear
In addition to clinical features in the previous reports, our genetic findings suggest the origin of retroperitoneal HGSC might be serous tubal intraepithelial carcinoma (STIC)
The knowledge that STIC cells migrate onto the peritoneum corresponds to the clinical feature of HGSC characterized by peritoneal dissemination and massive ascites
Summary
We presented a case of retroperitoneal HGSC possessing genetic relationship with STIC, suggesting that STIC is the precursor of retroperitoneal HGSC.
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