Concurrent infections by all four dengue virus serotypes during an outbreak of dengue in 2006 in Delhi, India

Randeep Guleria,Anubhav Pandey,Preeti Bharaj,Shobha Broor,Kavita Diddi,Harendra S Chahar,Sushil K Kabra,Lalit Dar

doi:10.1186/1743-422x-5-1

Randeep Guleria, Anubhav Pandey + Show 6 more

Open Access

https://doi.org/10.1186/1743-422x-5-1

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Journal: Virology Journal	Publication Date: Jan 9, 2008
Citations: 290	License type: cc-by

Affiliation: All India Institute of Medical Sciences

Abstract

BackgroundCo-circulation of multiple dengue virus serotypes has been reported from many parts of the world including India, however concurrent infection with more than one serotype of dengue viruses in the same individual is rarely documented. An outbreak of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) occurred in and around Delhi in 2006. This is the first report from India with high percentage of concurrent infections with different dengue virus serotypes circulating during one outbreak.ResultsAcute phase sera from patients were tested for the presence of dengue virus RNA by RT-PCR assay. Of the 69 samples tested for dengue virus RNA, 48 (69.5%) were found to be positive. All the four dengue virus serotypes were found to be co-circulating in this outbreak with DENV-3 being the predominant serotype. In addition in 9 of 48 (19%) dengue virus positive samples, concurrent infection with more than one dengue virus serotype were identified.ConclusionThis is the first report in which concurrent infections with different dengue virus serotypes is being reported during an outbreak from India. Delhi is now truly hyperendemic for dengue.

Highlights

Co-circulation of multiple dengue virus serotypes has been reported from many parts of the world including India, concurrent infection with more than one serotype of dengue viruses in the same individual is rarely documented
From India there is only one study in which we reported two cases of dual infection with DENV1 and DENV-3 serotypes [27]
Materials and methods A total of 69 blood samples were collected from patients with

Summary

Introduction

Co-circulation of multiple dengue virus serotypes has been reported from many parts of the world including India, concurrent infection with more than one serotype of dengue viruses in the same individual is rarely documented. An outbreak of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) occurred in and around Delhi in 2006. This is the first report from India with high percentage of concurrent infections with different dengue virus serotypes circulating during one outbreak. Infection with any one of these serotypes mostly causes a mild, self limiting febrile illness (classical dengue fever (DF)), a few cases develop severe life threatening dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). The estimated number of 50–100 million infections per year results in (page number not for citation purposes)

Results

Discussion

Conclusion