Concurrent Enhancement of Curcumin's Stability and Dissolution by the Preparation of its Eutectic Mixtures

Abstract

Rhizomes of Curcuma longa is the source of the chemical curcumin. It possesses several pharmacological characteristics, including anti-inflammatory, anti-hyperlipidemic antioxidant properties. But it also has several drawbacks, that limit its application as a medication. Curcumin's drawbacks that impede its application as a therapy include its poor chemical instability, solubility, bioavailability, and quick systemic clearance because of its rapid metabolism under physiological conditions. Its weak internal physicochemical properties make it less effective. These characteristics include photoinstability, limited bioavailability due to hydrolysis, and water insolubility. For the purpose of this investigation, a eutectic combination of 15% and 85% curcumin and nicotinamide was made. DSC, FTIR, and XRD analyses were used to assess the product's dissolving rate and photostability. The eutectic combination dissolved ten times faster after forty minutes than the parent medication. Following the 7th s day of accelerated photostability testing, curcumin-nicotinamide eutectic combinations shown 36% degradation, which was 34% less than pure curcumin. The photostability nvestigations were carried out in accordance with ICH Q1B recommendations. According to current research, cucumin may be a viable contender for pharmaceuticals in the future