Abstract

Concurrent Administration of Curcumin Mitigates Arsenic - and Chlorpyrifos - induced Apoptosis in Rat Thymocytes

Highlights

  • It is becoming increasingly evident that environmental exposures in humans and animals are not just limited to single chemicals

  • Arsenic and chlorpyrifos in combination potentiated the induction of apoptosis than their alone effect, concurrent administration of curcumin considerably inhibited the induction of apoptosis by scavenging free radicals

  • In West Bengal, more than 6 million people in nine districts are endemically exposed to inorganic arsenic by drinking heavily contaminated groundwater from hand–pumped tube–wells (Chowdhury et al, 2001) while Ballia district of eastern Uttar Pradesh (GOI, 2011) and arsenic contamination in Ganga–Meghna– Brahmaputra (GMB) plain (Chakraborti et al, 2010) are heavily contaminated with arsenic

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Summary

Introduction

It is becoming increasingly evident that environmental exposures in humans and animals are not just limited to single chemicals. Arsenic and chlorpyrifos in combination potentiated the induction of apoptosis than their alone effect, concurrent administration of curcumin considerably inhibited the induction of apoptosis by scavenging free radicals.

Results
Conclusion
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