Concurrence of oral and genital human papillomavirus infection in healthy men: a population-based cross-sectional study in rural China.

Fangfang Liu,Jingjing Li,Zhonghu He,Min Sun,Ying Liu,Tao Ning,Yang Ke,Hong Cai,Yaqi Pan,Lixin Zhang,Qiuju Deng,Chuanhai Guo,Chaoting Zhang,Yongmei Liang,Dong Hang,Longfu Xi,Mengfei Liu,Ruiping Xu

doi:10.1038/srep15637

Abstract

Human papillomavirus (HPV) infection, a primary cause of genital cancer, is also related to the increasing incidence of oropharyngeal cancer among young men. Relatively little is known about the concurrence of oral and genital infection among healthy individuals. Oral and genital swab exfoliated cells were collected simultaneously from 2566 men in rural China. Using general primer-mediated (SPF1/GP6+) PCR and sequencing, HPV testing results were obtained from 2228 men with both valid oral and genital specimens (β-globin-positive). The prevalence of HPV infection was 6.7% in the oral cavity and 16.9% for the external genitalia. Among 43 men (1.9%, 43/2228) with oral-genital coinfection, 60.5% (26/43) harbored an identical HPV type at both sites. The risk of oral HPV infection was higher among men with genital infection than among uninfected men (11.4% vs. 5.7%, Adjusted OR = 2.3, 95% CI: 1.6–3.4). In addition, having multiple lifetime sexual partners was a significant risk for oral-genital HPV coinfection (Adjusted OR = 2.6, 95% CI: 1.0–7.0; 2 partners vs. 1 partner). These findings provide a basis for further understanding the natural history and transmission dynamics of oral HPV infection.

Highlights

In sample size, have indicated that concurrent oral-genital Human papillomavirus (HPV) infections are rare and have reported inconsistent results regarding type-specific association of HPV infection at these two sites[10,11,12,13,14,15,16]
With respect to sexual behaviors, 81.7% reported occasionally or never washing external genitalia before sex, 14.6% reported having ≥ 2 lifetime sexual partners, and 3.9% had a history of oral sex practices
This population-based investigation of the concordance of HPV infections in the oral cavity and on the external genitalia is to our knowledge the first such investigation to be undertaken among Chinese men

Summary

Introduction

In sample size, have indicated that concurrent oral-genital HPV infections are rare and have reported inconsistent results regarding type-specific association of HPV infection at these two sites[10,11,12,13,14,15,16]. Concurrence of oral and genital HPV infection has rarely been investigated in a general male population. We reported an overall oral HPV prevalence of 6% in 5410 25–65 year old healthy males and females in rural China[17]. The intent of this study is to evaluate the association of HPV DNA simultaneously present in collected male external genital and oral specimens from this general population and identify relevant risk factors

Methods

Results

Conclusion