Abstract
We present the case of an eighteen-year-old Caucasian white boy who was diagnosed with xeroderma pigmentosum type A at age 5 and who experienced over the past year disseminated small plaque psoriasis confirmed with skin punch biopsy. The psoriatic lesions were successfully treated with multipotent topical corticosteroids and systemic retinoids. To our knowledge, the association between psoriasis and xeroderma pigmentosum has not been previously reported and may be regarded as unlikely when considering the pathogenesis of both diseases.
Highlights
Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder characterized by a defect of desoxy ribonucleic acid (DNA)-repair occurring during UV-induced damage
Basal cell carcinoma (BCC), squamous cell carcinoma (SCC), actinic keratoses, atypical moles and malignant melanoma, all associated with severe photoaging are commonly seen in such patients
Psoriatic plaques are characterized by immune activation, with natural killer (NK) cell activation and decreased cyclo-oxygenase activity [5,6]
Summary
Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder characterized by a defect of DNA-repair occurring during UV-induced damage. Patients with XP have a decreased cutaneous immune surveillance which results in an increased risk of UV-induced skin tumours at an early age. Basal cell carcinoma (BCC), squamous cell carcinoma (SCC), actinic keratoses, atypical moles and malignant melanoma, all associated with severe photoaging are commonly seen in such patients. Despite rigorous monitoring and photoprotection, the patient developed over 100 facial skin cancers (mainly BCC and SCC) treated with cryotherapy and surgery.
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