Abstract
BackgroundThe increased rates of cardiovascular morbidity and mortality in patients with psoriasis are not adequately explained by traditional risk factors. Whether concomitant sleep disorders (SDs) modify the risk of cardiovascular disease (CVD) in patients with psoriasis remains unknown.MethodsUsing the Taiwan National Health Insurance Research Database (NHIRD), we conducted a cohort study to investigate the association between concomitant SDs and CVD risk in patients with psoriasis. Data from 99,628 adults who received a psoriasis diagnosis during the period from 2004 to 2010 were analyzed. Cox proportional hazards regression analysis models were used to compare the risks of ischemic heart disease (IHD) and stroke between patients with and without SDs.ResultsPsoriasis patients with a concomitant SD had significantly higher risks of IHD (adjusted hazard ratio [aHR], 1.25; 95% confidence interval [CI], 1.22–1.28) and stroke (aHR, 1.24; 95% CI, 1.16–1.33) as compared with psoriasis patients without SDs. All psoriasis patient subgroups, including those with mild and severe psoriasis and those with and without arthritis, had increased HRs for IHD and stroke. The increases in IHD and stroke risks conferred by SDs were proportional to the dose of hypnotics used. The effect of SDs on the risks of IHD and stroke was greater in young adults than in middle-aged and older adults.ConclusionsThe risks of IHD and stroke were higher for psoriasis patients with SDs than for those without SDs. Clinicians should carefully evaluate CVD risk, particularly in young patients with psoriasis.
Highlights
Accumulating evidence suggests that psoriasis, a systemic inflammatory disorder, is associated with a variety of comorbidities, including diabetes, metabolic syndrome, chronic kidney disease, cardiovascular disease (CVD) and cerebrovascular disease [1,2,3,4,5,6,7]
Psoriasis patients with a concomitant sleep disorders (SDs) had significantly higher risks of ischemic heart disease (IHD) and stroke as compared with psoriasis patients without SDs
The risks of IHD and stroke were higher for psoriasis patients with SDs than for those without SDs
Summary
Accumulating evidence suggests that psoriasis, a systemic inflammatory disorder, is associated with a variety of comorbidities, including diabetes, metabolic syndrome, chronic kidney disease, cardiovascular disease (CVD) and cerebrovascular disease [1,2,3,4,5,6,7]. A casecontrol study by Wu et al showed that psoriasis is significantly associated with sleep disorders (SDs) and insomnia [11]. Poor sleep quality adversely affects quality of life [8]. It is not clear whether a concomitant SD modifies CVD risk in patients with psoriasis. We conducted a nationwide cohort study to investigate the association between concomitant SDs and CVD risk in patients with psoriasis. Whether concomitant sleep disorders (SDs) modify the risk of cardiovascular disease (CVD) in patients with psoriasis remains unknown
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
