Abstract
Mannose-binding lectin (MBL) deficiency is relatively common occurring in ∼7% of the general population. Most individuals with MBL deficiency are clinically unaffected due to protective antibody adaptive immunity, and therefore never present for evaluation of recurrent infections. We sought to identify associated immunologic abnormalities in patients with MBL deficiency that may have influenced their clinical presentation and resulted in referral for evaluation. Retrospective chart review of all patients found to have MBL deficiency at Cardinal Glennon Children's Medical Center at Saint Louis University between 2000 and 2009. Twenty-two patients, 40% of 55 patients with MBL deficiency, were found to have concomitant selective antibody deficiency (SAD). At initial evaluation Streptococcus pneumoniae antibody titers were frequently nonprotective in both groups of patients. After S. pneumoniae vaccination, MBL-deficient patients with SAD developed protective antibody titers to 44% ± 13% of S. pneumoniae sero...
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.