Abstract
The two opioid peptides dynorphin and α-neo-endorphin showed a parallelism in the temporal course of the neonatal development of their tissue levels within the neurointermediate pituitary of rats during the first 30 days of life. Moreover, dynorphin and α-neo-endorphin were found to be concomitantly released from isolated neurointermediate pituitaries of adult rats; the release could be stimulated by potassium in a Ca ++-dependent manner. These findings are in line with recent biochemical and immunohistochemical studies, showing that dynorphin and α-neo-endorphin are distributed in parallel and their levels are concomitantly regulated. This is consistent with the hypothesis that both peptides share a common biosynthetic pathway.
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