Concomitant Interstitial Lung Disease with Psoriasis.

Genta Ishikawa,Maria L Padilla,Samuel O Acquah,Sakshi Dua,Aditi Mathur,Mary Salvatore,Mary B Beasley

doi:10.1155/2019/5919304

Abstract

Background We encounter interstitial lung disease (ILD) patients with psoriasis. The aim of this case series was to examine clinical and radiographic characteristics of patients with concomitant psoriasis and ILD. Methods This is a retrospective review of our institutional experience of ILD concomitant with psoriasis, from the database in the Advanced Lung/Interstitial Lung Disease Program at the Mount Sinai Hospital. Out of 447 ILD patients, we identified 21 (4.7%) with antecedent or concomitant diagnosis of psoriasis. Clinical, radiographic, pathological, and outcome data were abstracted from our medical records. Results Median age was 66 years (range, 46–86) and 14 (66.7%) were male. Thirteen (61.9%) had not previously or concomitantly been exposed to immunosuppressive therapy directed against psoriasis. Two (9.5%) ultimately died. Clinical diagnosis of ILD included idiopathic pulmonary fibrosis, 11 (52.4%); nonspecific interstitial pneumonia (NSIP), 2 (9.5%); cryptogenic organizing pneumonia, 2 (9.5%); chronic hypersensitivity pneumonitis, 2 (9.5%); and the others, while radiographic diagnosis included usual interstitial pneumonia pattern, 9 (42.9%); NSIP pattern, 6 (28.6%); organizing pneumonia pattern, 4 (19.0%); hypersensitivity pneumonitis pattern, 2 (9.5%); and the others. Conclusions We report 21 ILD cases with antecedent or concomitant diagnosis of psoriasis. Further prospective studies are required to determine the association between ILD and psoriasis.

Highlights

Psoriasis commonly presents with sharply defined erythematous plaques with overlying silvery scales. e scalp, elbow extensors, knees, and back are common locations for plaque psoriasis [1]. is hyperproliferative state is characterised by increased numbers of epidermal stem cells and cells undergoing DNA synthesis, shortened keratinocyte cell cycle time, and decreased epidermal turnover time [1]
Psoriatic arthritis is an inflammatory arthritis/synovitis that occurs in 25% of patients with psoriasis; it is a distinct clinical entity characterised by involvement of the distal interphalangeal joints of the hands and feet as well as the absence of rheumatoid factor [2]
Patients. is case series was a retrospective review of our institutional experience with interstitial lung disease (ILD) concomitant with psoriasis at the Advanced Lung/Interstitial Lung Disease Program at Mount Sinai Hospital, New York. e medical records of 447 consecutive patients who visited the ILD program were reviewed retrospectively. e inclusion criteria were as follows: (1) patients who visited the Advanced Lung/Interstitial Lung Disease Program from October 2009 through September 2015, (2) age ≥ 18 years old, (3) a diagnosis of ILD, and (4) diagnosed with either psoriasis or psoriatic arthritis by dermatologists

Summary

Introduction

Psoriasis commonly presents with sharply defined erythematous plaques with overlying silvery scales. e scalp, elbow extensors, knees, and back are common locations for plaque psoriasis [1]. is hyperproliferative state is characterised by increased numbers of epidermal stem cells and cells undergoing DNA synthesis, shortened keratinocyte cell cycle time, and decreased epidermal turnover time [1]. A previous small study (N 50) in the Tucson VA Hospital showed that pulmonary fibrosis was not more common in a population of patients with psoriasis than would be expected in a control. We encounter interstitial lung disease (ILD) patients with psoriasis. E aim of this case series was to examine clinical and radiographic characteristics of patients with concomitant psoriasis and ILD. Is is a retrospective review of our institutional experience of ILD concomitant with psoriasis, from the database in the Advanced Lung/Interstitial Lung Disease Program at the Mount Sinai Hospital. Out of 447 ILD patients, we identified 21 (4.7%) with antecedent or concomitant diagnosis of psoriasis. We report 21 ILD cases with antecedent or concomitant diagnosis of psoriasis. Further prospective studies are required to determine the association between ILD and psoriasis

Methods

Results

Conclusion