Abstract
5534 Background: Concomitant platinum-based chemoradiation (CRT) is the standard treatment for locally advanced squamous cell carcinoma. As no consensus regarding the optimal concomitant platinum-based regimen exist, a literature based meta-analysis was performed. Methods: Randomized trials comparing radiation alone (RT) vs concomitant platinum-based CRT were identified by electronic search. The main endpoints were to compare the efficacy with regards to cisplatin total dose and platinum compounds (cisplatin vs carboplatin). Hazard ratios (HRs) and their 95% confidence intervals (CIs) were used to measure the relative effect of treatments on overall survival (OS). Heterogeneity among trials wastested by Chi-Square test and I2index. The incidence of Grade (G) 3-4 mucositis was also analyzed by means of a Chi-Square test. Results: Fifteen trials were identified and 2502 patients were available for the analysis. No difference in OS was observed between cisplatin high dose (300mg/sqm) (HR 0.59, 95% CI 0.46-0....
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