Abstract
AbstractBetuphenone F (6) is a natural product isolated from the bark of Betula alnoides Ham. ex D. Don (Betulaceae) and structurally determined by S. Awale et al. in 2021. Betuphenone F (6) has the potential to be a new‐generation anti‐cancer agents based on anti‐austerity, as it showed preferential cytotoxicity against PANC‐1 human pancreatic cancer cells under nutrient‐deprived conditions (PC50 value of 4.9 μM). We succeeded in constructing the 2‐oxabicyclo[3.3.1]nonane skeleton, which is a structural feature of betuphenone F (6), by exposing intermediate 9 to acid, and achieved the first total synthesis of rac‐bethuphenone F (6) from phloroglucinol (7) in only three steps.
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