Concise Synthesis of Deformylflustrabromine, a Marine Indole Alkaloid, through a 2-Propynyl Dicobalt Hexacarbonyl Complex

Abstract

Abstract Deformylflustrabromine, a marine indole alkaloid, was synthesized from 6-bromotryptamine, a plausible biosynthetic precursor, without protection of the amino group by a two-step reverse prenylation involving the Nicholas reaction and reductive decomplexation of the resulting acetylene dicobalt hexacarbonyl complex.