Concise synthesis of α-alkyl α-amino acids and their incorporation into peptides viaβ-lactam-derived α-amino acid N-carboxy anhydrides

Abstract

α-Hydroxy β-lactams in which C4 exists as a quaternary carbon are transformed in a single one-pot operation into α,α-dialkyl α-amino acid N-carboxy anhydrides providing a new approach to conformationally restricted peptide segments from non α-amino acid precursors.