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Abstract
Novel acyclic nucleoside analogues were designed and synthesized as open-chain analogues of neplanocin A. The coupling of the allylic bromide with pyrimidine bases using cesium carbonate afforded a series of novel acyclic nucleosides. The synthesized compounds 15–22 were evaluated for their antiviral activity against various viruses such as HIV, HSV-1, HSV-2, and HCMV.
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