Abstract
Concise Review: Appreciated Signaling Role of High Mobility Group-A Proteins for Regulation of Proliferation, Pluripotency and Self-Renewal of Adult Stem Cells
Highlights
Stem cells were primarily studied by Becker’s group, when they observed development of splenic nodules after inoculation of bone marrow mononuclear cells into irradiated mice
Recent perception proposed that the adult tissues contain primitive pluripotent stem cells (Kucia et al, 2007; Santourlidis et al, 2011; Roger et al, 2012; Ogura et al, 2014). The employment of these recent identified adult pluripotent stem cells potentially for organs regeneration needs to address the biological keys [i.e., high mobility group proteins–A], that play a crucial role in maintaining the self-renewal and pluripotency features of these cells especially after theirimplantation (Ismail et al, 2012)
Who declared that up regulation of these unique proteins in unspecialized and primitive stem cells isolated from embryos revealed the crucial role of hmga proteins in management of stem cell differentiation and proliferation
Summary
Stem cells were primarily studied by Becker’s group, when they observed development of splenic nodules after inoculation of bone marrow mononuclear cells into irradiated mice. Keywords | Self-renewal, Pluripotency, Stem cells, hmga, Proliferation
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