Concerns regarding NMR lipoprotein analyses performed on the Nightingale heath platform – Focus on LDL subclasses

Abstract

Heterogeneity within each of the major classes of lipoprotein particles is well-recognized, with multiple subspecies that vary in size, density, and chemical composition. 1 Chapman MJ Orsoni A Tan R Mellett NA Nguyen A Robillard P et al. LDL subclass lipidomics in atherogenic dyslipidemia: effect of statin therapy on bioactive lipids and dense LDL. J Lipid Res. 2020; 61: 911-932 Abstract Full Text Full Text PDF PubMed Google Scholar ,2 Krauss RM. Lipoprotein subfractions and cardiovascular disease risk. Curr Opin Lipidol. 2010; 21: 305-311 Crossref PubMed Scopus (176) Google Scholar Certain of these, for example small, dense LDL, are known to have potent atherogenic properties, and increases in their plasma levels are associated with heightened risk of atherosclerotic cardiovascular disease, 3 Boren J Chapman MJ Krauss RM Packard CJ Bentzon JF Binder CJ et al. Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel. Eur Heart J. 2020; 41: 2313-2330 Crossref PubMed Scopus (303) Google Scholar as well as cardiometabolic disorders such as diabetes mellitus. 4 Mora S Otvos JD Rosenson RS Pradhan A Buring JE Ridker PM. Lipoprotein particle size and concentration by nuclear magnetic resonance and incident type 2 diabetes in women. Diabetes. 2010; 59: 1153-1160 Crossref PubMed Scopus (115) Google Scholar Moreover, developmental strategies for new lipid lowering therapies are now presenting the potential for targeting of specific atherogenic lipoprotein particle subfractions with the goal of optimizing clinical benefit. For these reasons, there is a growing and important need in both scientific and clinical communities to accurately determine the plasma concentrations of these subfractions. 5 Wilson PWF Jacobson TA Martin SS Jackson EA Le NA Davidson MH et al. Lipid measurements in the management of cardiovascular diseases: Practical recommendations a scientific statement from the national lipid association writing group. J Clin Lipidol. 2021; Abstract Full Text Full Text PDF Scopus (7) Google Scholar