Abstract
We read with great interest the recent article CD-1 and Balb/cJ mice do not show enduring antidepressant-like effects of ketamine in tests of acute antidepressant efficacy by Bechtholt-Gompf et al. (in press). In that study, the tail suspension test (TST) and forced swimming test (FST) were not sensitive to long-lasting antidepressant-like effects of ketamine in mice. We appreciate this study and would like to discuss an issue relevant to this article. The authors administrated high-dose ketamine to observe the behavioral changes in the FST and TST. However, the administration of ketamine 25 mg/kg induces an immediate behavioral activation, characterized by hyperlocomotion,
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