Abstract
ABSTRACT.The ability to selectively depress paroxysmal firing of neurons in the reticular formation appears to be the common denominator of antiepileptic drug action. This property enables antiepileptic drugs to prevent the spread of seizure activity without significantly impairing normal neuronal activity, so that they can stop seizures without producing significant sedative side effects. The various classes of antiepileptic drugs exert these actions by different mechanisms, leading to a preferential action on different neuronal pathways and on different types of seizures. Drugs effective against absence seizures depress inhibitory pathways while drugs effective against tonic-clonic seizures also depress excitatory pathways. The selective action of antiabsence drugs on inhibitory pathways corresponds to the clinical and experimental evidence that absence seizures are due to paroxysmal discharges in inhibitory pathways in the central nervous system (CNS). The search for the mechanisms of action of antiepi...
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