Abstract
In biosensors biological macromolecules, mainly proteins, are used for complementary substrate recognition. Unfortunately these systems suffer from chemical and thermal instability, which is unsatisfactory for applications, e.g. in controlling fermentation processes or in vivo monitoring. On the other hand artificial ‘receptors’ with a reasonable selectivity and even catalytic activity become available with the growing field of supramolecular chemistry. Molecular modeling studies for space optimization using calixarenes as receptor molecules and calculation of binding constants between different host and guest molecules are shown. Using a quartz crystal microbalance system first results are given for the binding of compound 3 to a thiol modified quartz crystal surface followed by attempts to detect the binding of saccharides to the receptor modified surface.
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