Concentrations of Tissue Plasminogen Activator and Plasminogen Activator Inhibitor-1 Antigen in Blood Obtained from the Patients with a First-time, Recurrent, or Chronic Cerebral Infarction

Abstract

We have already reported about fluctuations of tissue plasminogen activator (t-PA) activity, t-PA antigen, plasminogen activator inhibitor-1 (PAI-1) antigen and t-PA index ((t-PA activity ng/ml)/(t-PA antigen ng/ml)×100) in blood obtained from patients with acute cerebral infarction (CI).Most patients were plotted out to the abnormal range by a scattergram relating t-PA activity to t-PA antigen, and showed a powerful correlation between PAI-1 inhibitor and t-PA index, suggesting the influential regulation of PAI-1. In this report, we designed to investigate the fibrinolytic parameters, including t-PA activity, t-PA antigen, PAI-1 antigen, t-PA index and T/P 100 ((t-PA antigen ng/ml)/(PAI-1 antgen ng/ml)×100) in acute phase of a first-time or recurrent CI, and chronic one.The results were as follows: the mean value of t-PA activity, t-PA antigen, t-PA index, PAI-1 antigen and T/P100 were higher than those of healthy controls. Although no significant differences were shown between these fibrinolytic parameters of a first CI and a reinfarction, chronic CI presented significantly higher t-PA activity than a first orrecur-rent acute CI. It is considered to be important to clarify pathophysiological differences of fibrinolytic mechanism between acute and chronic CI.